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2CB Tolerance How to Address or Decrease it Safely

Tolerance to a drug refers to the body’s inability to respond to a drug the way it did when a person began using it. That is, a person starts to need higher and higher doses of the same substance to achieve the same effects, according to the National Institute on Drug Abuse (NIDA). Tolerance is not the same as addiction, but it can make addiction more likely.

What Is 2C-B, and Why Is Tolerance a Risk? 

A hallucinogenic drug, 2C-B is similar to mescaline. It belongs to a category of drugs that contains phenylethylamine (PEA).

This substance is linked to a feeling of pleasure and euphoria. It is known to exist in lesser quantities in the urine of people who are depressed.

Some scientists are conducting research to know whether or not depression can be traced to having less PEA. PEA is also present in chocolate. Though this is true, consuming chocolate does not increase levels of PEA because it is quickly metabolized.

The drug 2C-B was first created in a lab in 1974 by Dr. Alexander Shulgin. It is in the same category as drugs such as MDMA (ecstasy) because of its similar effects. In fact, it is often sold as a substitute for ecstasy and has similar side effects.

It is known as a novel psychoactive substance (NPS). This is a type of drug that has emerged in response to laws against other types of substances, according to the Journal of Analytical Toxicology. NPS drugs are also known as bath salts, legal highs, or designer drugs because they were manufactured in laboratories. They are also often created to get around legal issues related to better-known controlled substances.  

Effects of 2C-B

The substance has both psychological and physical effects. It is available as a powder, but it can also be purchased as a tablet. Like MDMA, no one checks the quality of the substance – neither the dealer or buyer. People who take 2C-B are at risk of ingesting contaminants.

According to The Irish Mirror, the full effects of 2C-B have not been studied. Still, some people have said the effects of 2C-B have lasted anywhere from 10 hours to 24 hours. Various rave and drug forums mention that the effects of 2C-B depend on how much is taken and how it is taken. The average dose when swallowing 2C-B is between 5 milligrams (mg) and 25 mg, and between 5 mg and 15 mg if snorted.

Other things to know about 2C-B’s effects include:

  • They depend on the state of mind of the person using it.
  • The effects may take 5 minutes to 10 minutes to be felt when snorting the drug or 30 to 60 minutes if it is swallowed.
  • Its influence peaks at 1.5 hours.
  • It can amplify the senses and the experience can be affected by music.
  • Some people report synesthesia when under 2C-B’s influence.

Short-Term and Long-Term Side Effects

2C-B produces both short-term and long-term side effects.

Short-term side effects include:

  • Burning in the mucus membranes from snorting the substance
  • Increase in temperature and heart rates
  • Slower reaction times and loss of coordination
  • Bad trips from larger doses
  • Distortion of perception

Some people report intense dreams after coming off a 2C-B high. Others find they become more social and empathetic under 2C-B’s effects. Others report feelings of paranoia, distortions when looking at faces, or thoughts of despair. 

Research is still being conducted on the long-term effects of 2C-B. It is not yet known how much a dosage should contain to be lethal. There is some evidence that taking 2C-B could worsen mental health issues in some people.

Things to Watch Out For

Use of 2C-B affects attention span and coordination. As such, people who take this drug should avoid driving a vehicle or operating machinery.

Adding just 2 mg to the dosage one usually takes is enough to change the effects that are usually experienced. Many who use 2C-B report tolerance if they use it frequently.

People should not mix 2C-B with cocaine, mescaline, Tramadol, and amphetamine, as the effects of these combinations can be dangerous.

Recognizing Tolerance to 2C-B

More research needs to be conducted on tolerance to substances like 2C-B; however, there is some knowledge about tolerance to NPS in general. This may help users potentially understand their use of 2C-B.

Overall, it can be difficult to track a person’s use of an NPS substance such as 2C-B. That is because many urine-based drug tests are not sensitive to its chemical makeup.

According to NIDA, a person experiences drug tolerance when they need the substance in higher doses to feel the same way they did when they first tried it. People who use 2C-B more than one time during a five-to-seven day period report a higher buildup of tolerance than less frequent users.

The brain is known to rewire itself once the body gets used to a certain drug. For example, the brain reduces the number of reward neurons it fires once a person becomes tolerant of a substance. This may make a person feel sluggish or depressed when they are not using their substance of choice. Eventually, this could transform into tolerance as the brain requires the substance that provides it with a feeling of reward.  

The liver also begins to activate more and more enzymes that allow the body to metabolize a given substance.

What to Do If You Become 2C-B Tolerant 

More research is needed to know what specific symptoms people should look out for if they become tolerant to 2C-B. As with any other substance, a common sign of 2C-B tolerance is larger doses are required to feel pleasure.

Tolerance in and of itself does not mean a person will become addicted to 2C-B, but it does increase the chances of dependency and misuse. In fact, tolerance can be a sign of dependency for people who misuse 2C-B. 

People who feel they have become dependent on 2C-B can look out for symptoms, such as:

  • An inability to control cravings or use despite adverse effects
  • Changes to functions on a daily basis
  • Withdrawal symptoms when without 2C-B

Reducing or Stopping Use of 2C-B

If you recognize a pattern of misuse, it is a good idea to consult with a qualified physician to discuss treatment options. Rehab can help you leave behind substance abuse and embrace a healthy life in recovery.

More research needs to be conducted on whether or not it is best to quit 2C-B cold turkey or take smaller doses gradually. If you have been using a substance for a long time or in high doses, it is not advisable to quit cold turkey. The body’s nervous system might be used to functioning with 2C-B present. Tolerance might make quitting all of a sudden much more difficult.

In addition, quitting suddenly will make a person less tolerant of a substance. This means that if the person relapse, they run the risk of overdosing if they decide to take the substance in the amounts they did before.

Medical professionals and addiction treatment specialists can advise you on the best path forward for your specific situation.

Sources

What is 2C-B? DanceSafe. Retrieved December 2018 from https://dancesafe.org/2c-b/

The Essential Guide to 2C-B. The Third Wave. Retrieved December 2018 from https://thethirdwave.co/psychedelics/2c-b/

My Night on 2CB. The Tab. Retrieved December 2018 from https://thetab.com/uk/liverpool/2013/02/25/my-night-on-2cb-5049

What is new designer drug 2CB and why is it so dangerous? Irish Mirror. Retrieved December 2018 from https://www.irishmirror.ie/news/irish-news/health-news/what-new-designer-drug-2cb-7207061

2C-B. Science Direct. Retrieved December 2018 from https://www.sciencedirect.com/topics/neuroscience/2c-b

(January 2013) Six in hospital after taking hallucinogen. The Guardian. Retrieved December 2018 from https://www.theguardian.com/society/2013/jan/11/six-in-hospital-hallucinogen-2cb

(May 2001) Information Bulletin: 2C-B (Nexus) Reappears in the Drug Scene. Department of Justice. Retrieved December 2018 from https://www.justice.gov/archive/ndic/pubs0/665/index.htm

(August 2014) Avon and Wiltshire Mental Health Partnership NHS Trust. NHS. Retrieved December 2018 from http://www.awp.nhs.uk/media/707352/hmp-bristol-know-the-effects-2cb-082017.pdf

(January 2017) Mistaking 2C-P for 2C-B: What A Difference A Letter Makes. Journal of Analytical Toxicology. Retrieved December 2018 from https://academic.oup.com/jat/article/41/1/77/2527459

(March 2018) Acute Pharmacological Effects of 2C-B in Humans: An Observational Study. Frontiers in Pharmacology. Retrieved December 2018 f from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859368/

(October 2015) Acute Effects of the Novel Psychoactive Drug 2C-B on Emotions. BioMed Research International. Retrieved December 2018 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620274/

(March 2012) Phenylethylamine (PEA) and Tyramine. Molecule of the Month. Retrieved December 2018 from http://www.chm.bris.ac.uk/motm/pea/peah.htm

2C-B. DrugScouts. Retrieved December 2018 from https://drugscouts.de/en/lexikon/2c-b

(January 2017) Novel psychoactive substances: identifying and managing acute and chronic harmful use. The BMJ. Retrieved on December 2018 from https://www.bmj.com/content/356/bmj.i6814

Tolerance and Resistance to Drugs. MSD Manuals. Retrieved December 2018 from https://www.msdmanuals.com/home/drugs/factors-affecting-response-to-drugs/tolerance-and-resistance-to-drugs

What Are the Effects of Ecstasy? Scientific American. Retrieved December 2018 from https://www.scientificamerican.com/article/what-are-the-effects-of-t/

(Feburary 2018) What Are the Risks of Quitting Substance Use Cold Turkey? Verywell Mind. Retrieved December 2018 from https://www.verywellmind.com/what-are-the-risks-of-quitting-cold-turkey-21813

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