Mysoline Withdrawal

Mysoline (generic name primidone) is a barbiturate used to treat seizures. While it can be beneficial as a treatment for epilepsy and benign essential tremor, Mysoline can be very dangerous because it is highly addictive. And, like other barbiturates, the difference between a prescribed dose and overdose is slim. Barbiturates are not commonly prescribed anymore because they are so risky. If dependence or addiction occurs, Mysoline withdrawal can be difficult. The withdrawal symptoms are severe and can be deadly. Because of this, it’s essential to participate in a professional addiction treatment program during the detox and recovery process.

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Fighting Addiction Yourself is Difficult. Let Our Experts Help!

Fighting Addiction Yourself is Difficult. Let Our Experts Help!

What Are the Mysoline Withdrawal Symptoms?

Mysoline is a central nervous system depressant that binds to the GABA neurotransmitters in the brain. GABA produces feelings of calm. Mysoline causes the mind to think that it is GABA. This is how the sensations of deep relaxation and sedation generate.

The difference between a prescribed dose and an overdose of Mysoline is small. Because Mysoline is such a powerful sedative, it can also be easy to develop a dependence on, or addiction to, this drug. Once you become dependent on Mysoline, it can be difficult to quit taking it, and you will experience Mysoline withdrawal symptoms.

Mysoline withdrawal can be very dangerous, and even deadly. Up to 75 percent of people withdrawing from barbiturates experience seizures, and up to 66 percent may experience delirium that lasts several days. Symptoms of Mysoline withdrawal include:

  • Tremors
  • Trouble sleeping
  • Restlessness
  • Irritability
  • Stomach cramps
  • Nausea
  • Vomiting
  • Suicidal thoughts
  • Hallucinations
  • High temperature
  • Seizures
  • Heart failure
  • Death

What Are the Stages of the Mysoline Withdrawal Timeline?

Minor Mysoline withdrawal symptoms start around eight to 12 hours after the last dose. These symptoms may include:

  • Anxiety
  • Muscle twitching
  • Hand tremors
  • Weakness
  • Dizziness
  • Distorted vision
  • Nausea
  • Vomiting
  • Insomnia
  • Low blood pressure

Major Mysoline withdrawal symptoms occur about 16 hours after the last dose. These symptoms last for about five days and include:

  • Convulsions
  • Delirium

Sometimes certain barbiturate withdrawal symptoms—particularly mental and emotional symptoms—may last for several months or years.

Why Should I Detox?

Trying to quit taking drugs cold turkey can be difficult and painful. In some cases, it can even be deadly, such as when withdrawing from barbiturates like Mysoline.

Because of the difficult physical and psychological symptoms, going through withdrawal on your own can be difficult whether you go cold turkey or not. This is why it’s so important to find a medically-assisted detox program to support you during Mysoline withdrawal. A professional addiction treatment program ensures that you will be carefully monitored by a medical team in a safe environment while your body goes through the detoxification process. You also have a better chance at lasting recovery by participating in an addiction treatment program because of the structured medical and emotional support provided.

What Is the Next Treatment Step?

Following a full continuum of treatment is the best way to ensure a successful recovery because withdrawal from barbiturates like Mysoline can be dangerous and even deadly. A full continuum treatment plan starts with the medical detox process, then progresses in stages from an inpatient status to an outpatient level of treatment:

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The first stage of withdrawal treatment is detox. The goal is medical stabilization during this stage. The detox stage lasts from a few days up to a week. When you arrive, you will receive a complete medical assessment to determine your level of addiction, plus any additional medical needs you may have. The assessment will include a medical exam and urine or blood tests to screen for drugs.

Your medical team, which includes doctors, nurses, and support staff, will monitor you 24/7 to help manage uncomfortable withdrawal symptoms and prevent dangerous sedative withdrawal symptoms.

Many people also experience anxiety, depression, and other emotional and psychological challenges. Because of this, your treatment plan will also include emotional support. Your doctor will develop a longer-term treatment plan for you once you are medically stabilized.


You might continue with the next stage of treatment on a residential basis if you require further medical treatment. If you have co-occurring medical conditions or if you are experiencing further post-acute withdrawal symptoms, your doctor may recommend further inpatient treatment. This level of treatment is intensive and includes 24/7 medical monitoring. You will also begin seeing a therapist on a regular basis.


Partial-hospitalization (PHP) is the next stage of treatment, either after detox or after further inpatient care. PHP is like a cross between inpatient care and outpatient treatment. During this stage, you’ll reside at a transitional living facility while undergoing a supportive, rigorous, and structured treatment program five days a week for six hours each day. You will be able to participate in individual, group, and family therapy programs to address your emotional and mental health needs. At this stage, the focus will be on learning positive life skills, coping mechanisms, and techniques to help prevent relapse and help you to be better prepared for long-term recovery.


After PHP, the next stage is the intensive outpatient program, or IOP. This level of treatment allows you to live at home while still participating in counseling and programs designed to help support you in your recovery process. You will participate in about nine or more hours of clinical therapy each week, depending on your treatment plan. These sessions are scheduled several times over the course of each week. You will continue learning strategies and tools to cope with cravings, stress, and other issues that may come up as you move back into regular day-to-day living.


After completing the formal treatment program, you will have the opportunity to get to know other treatment center alumni. Aftercare programming such as weekly support groups and social events provides opportunities to meet other program graduates and develop new friendships.

Building a social support system with others who understand the recovery process can help you grow and stay focused on your recovery as you continue to adjust to life after the treatment program. It can also be a great way to share relapse prevention strategies, new experiences, techniques to manage stress and frustration. Most of all, it simply can be a way to enjoy spending time with new friends.

Start Your Journey to Recovery Today

If you need help with Mysoline withdrawal, contact the admissions specialists at Ocean Breeze Recovery for free and confidential help. Our specialists are available 24/7 to provide guidance and support. They will explain the treatment process with you and answer any questions you may have.

After speaking with a specialist, you will know what to expect from our evidence-based services and you will feel prepared to make an informed decision about your treatment plans. Our specialists can also check with your private health insurance to see if your treatment costs will be fully covered. You don’t have to go through this alone. Call us today at 844-554-9279 and let us help you start your journey to recovery today.