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Mysoline Withdrawal | Timeline, Symptoms, Detox

Mysoline (generic name primidone) is a barbiturate used to treat seizures. While it can be beneficial as a treatment for epilepsy and benign essential tremor, Mysoline can be very dangerous because it is highly addictive. And, like other barbiturates, the difference between a prescribed dose and overdose is slim. Barbiturates are not commonly prescribed anymore because they are so risky. If dependence or addiction occurs, Mysoline withdrawal can be difficult. The withdrawal symptoms are severe and can be deadly. Because of this, it’s essential to participate in a professional addiction treatment program during the detox and recovery process.

What Are the Mysoline Withdrawal Symptoms?

Mysoline is a central nervous system depressant that binds to the GABA receptors in the brain, which causes the sensations of deep relaxation and sedation.

The difference between a prescribed dose and an overdose of Mysoline is small. Because Mysoline is such a powerful sedative, it can also be easy to develop tolerance and dependence for the substance. Once you become dependent on Mysoline, it can be difficult to quit taking it, and you will experience Mysoline withdrawal symptoms.

Mysoline withdrawal can be very dangerous, and even deadly. Up to 75 percent of people withdrawing from barbiturates experience seizures, and up to 66 percent may experience delirium that lasts several days.

Symptoms of Mysoline withdrawal include:

  • Tremors
  • Trouble sleeping
  • Restlessness
  • Irritability
  • Stomach cramps
  • Nausea
  • Vomiting
  • Suicidal thoughts
  • Hallucinations
  • High temperature
  • Seizures
  • Heart failure
  • Death

What Are the Stages of the Mysoline Withdrawal Timeline?

Minor Mysoline withdrawal symptoms start around eight to 12 hours after the last dose. These symptoms may include:

  • Anxiety
  • Muscle twitching
  • Hand tremors
  • Weakness
  • Dizziness
  • Distorted vision
  • Nausea
  • Vomiting
  • Insomnia
  • Low blood pressure

Major Mysoline withdrawal symptoms occur about 16 hours after the last dose. These symptoms last for about five days and include:

  • Convulsions
  • Delirium

Sometimes certain barbiturate withdrawal symptoms—particularly mental and emotional symptoms—may last for several months or years. 

Why Should I Detox?

Quitting drugs cold turkey may sound like a good idea, but it can be difficult, painful, and dangerous. In some cases, it can be dangerous and even deadly.

Given the difficult physical symptoms, withdrawing on your own without professional medical help can be very challenging. It’s important to find a professional, medically assisted detox program to support you during the process of Mysoline withdrawal.

Doing this will ensure that you are carefully monitored in a safe environment while your body goes through the difficult detoxification process. Participating in an addiction treatment program also gives you a better chance at lasting recovery as a result of the structured medical and emotional support you will receive.

What Is the Next Treatment Step?

A full continuum of treatment ensures the best opportunity for a successful recovery. Following a full continuum of treatment means starting with the medical detox process and then progressing gradually from an inpatient status to outpatient treatment. You will then have the opportunity to participate in an alumni program after the formal treatment program is completed. The stages of addiction treatment include:


The primary goal is medical stabilization during the first stage of withdrawal treatment, which is known as detox. Expect the detox stage to last from a few days up to a week. When you arrive, your medical team—which will include doctors, nurses, and support staff— will complete your comprehensive medical assessment, which will help determine your level of addiction and additional medical needs you may have. The assessment includes a medical exam plus a urine screening for drugs.

Your medical team will monitor you 24/7 to help manage uncomfortable withdrawal symptoms and prevent dangerous Mysoline withdrawal symptoms.

Many people also experience anxiety, depression, and other emotional and psychological challenges during the detox period. Your treatment plan will also include comprehensive support to help you with these symptoms. A longer-term treatment plan will be put into place for you once you are medically stabilized.


If you and the treatment team determine that you need further medical treatment, you may continue the next stage of treatment on an inpatient basis, which might be because of co-occurring medical conditions or post-acute withdrawal symptoms. Inpatient treatment is intensive and includes 24/7 clinical monitoring. At this stage, you will start seeing a therapist regularly to help you process the emotional and psychological aspects of addiction and recovery.


Partial hospitalization (PHP) is in-between outpatient treatment and inpatient care. The goal of PHP is to stabilize your mental status and better prepare you for success once you return to independent living after you leave the treatment center. During this stage, you’ll live at a transitional living facility while undergoing a supportive and rigorous treatment program. This program will be five days a week for six hours each day. You will be able to participate in individual, group, and family therapy programs to help you address emotional and mental health needs.

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Learning positive life skills, coping mechanisms, and techniques to help prevent relapse so that you will be prepared for long-term recovery will be the primary focus during PHP.

Intensive Outpatient

The next stage is the intensive outpatient program (IOP). An IOP allows you to live at home while also attending counseling and programs to help support your recovery. Depending on your treatment plan, you will participate in about nine or more hours of clinical therapy several times each week.

Intensive outpatient therapy will help you to continue learning new ways to manage cravings, stress, and other challenging issues that may arise once you live on your own again. After you complete the IOP stage, you will transition into the Outpatient and Alumni programs, which is also known as aftercare.


You will have the opportunity to meet other treatment center alumni during weekly support groups and social events after you complete the formal treatment program. These aftercare opportunities spent with other alumni members can help you develop new friendships and build social support with others who understand the recovery process.

Being a part of this supportive network can help you grow while focusing on your recovery and adjusting to life after the treatment program. It can also be a safe space to share relapse prevention strategies, new experiences, and techniques for stress management. Most of all, it can be a way to enjoy time with new friends.

Start Your Journey to Recovery Today

If you need help with Mysoline withdrawal, contact the admissions specialists at Ocean Breeze Recovery for free and confidential help. Our specialists are available 24/7 to provide guidance and support. They will explain the treatment process with you and answer any questions you may have.

After speaking with a specialist, you will know what to expect from our evidence-based services and you will feel prepared to make an informed decision about your treatment plans. Our specialists can also check with your private health insurance to see if your treatment costs will be fully covered. You don’t have to go through this alone. Call us today at 844-554-9279 and let us help you start your journey to recovery today.

Sources (2019, February 18) Mysoline. Retrieved from

MedicineNet. Barbiturates. Davis, P. MD Ph.D. Retrieved from

Psychology Today. (2010, January 13) Alcohol, Benzos, and Opiates — Withdrawal That Might Kill You. Jaffe, A. Retrieved from

MedicalNewsToday. (2018, June 25) Everything you need to know about barbiturates. Withdrawal Symptoms. Davis, K. Retrieved from

NIDA. (2020, June 3). Types of Treatment Programs. Retrieved from

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